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Shubha Tole' (born August 1967) is an Indian neuroscientist, professor and principal Investigator at the Tata Institute of Fundamental Research in Mumbai, India. Her research investigates the development and evolution of the mammalian brain. In 2014, she won the Infosys Prize in the Life Sciences category.
Shubha Tole | |
|---|---|
| Born | August 1967 (age 56) |
| Nationality | Indian |
| Education | St Xavier's, Mumbai California Institute of Technology, USA |
| Occupation | Neuroscientist |
| Employer | Tata Institute of Fundamental Research |
| Spouse | Sandip Trivedi |
| Children | 2 |
Early life and education edit
Tole was born in August 1967 in India. Her mother, Aruna P. Tole, was an occupational therapist responsible for the design of prostheses, aids, and appliances for cancer patients.[1] Her father was the director of SAMEER, an institute under the Department of Electronics, Government of India,[2] in August 1967.
Tole studied life sciences and biochemistry at St. Xavier’s College in Mumbai and earned her master's and doctoral degrees at the California Institute of Technology in the United States. Tole conducted post-doctoral research at the University of Chicago.[3]
Research and career edit
In 1999, Dr. Tole started her research group at the Tata Institute of Fundamental Research, Mumbai.[4]
Dr. Tole and her research group is credited with the discovery of the role of the regulatory gene LHX2, which controls aspects of how the amygdala, cortex, and hippocampus form during early brain development. Dr. Tole's research group also proposed a possible mechanism for how the neocortex may have come to be in mammals, linking it to a much older structure of the brain, the amygdala. Her research group also discovered dual developmental origins for structures that control reproductive and aggressive behavior in the accessory olfactory bulb in mammals.[5]
Tole has also held a membership with academic groups such as the International Affairs Committee of the American Society for Cell Biology. She is also a Fellow of the National Academy of Sciences, India and the Indian Academy of Sciences.[3]
Personal life edit
Dr. Tole is married to theoretical physicist Sandip Trivedi since 1989. They have two sons.[6]
Honors and awards edit
Tole has received the Wellcome Trust Senior International Fellowship (1999), the Swarnajayanti Fellowship from the Department of Science and Technology of the Government of India (2005), the National Woman Bioscientist award from the Department of Biotechnology of Government of India (2008), the Research Award for Innovation in Neurosciences (RAIN award) from the Society for Neuroscience, United States (2008), and the Shanti Swarup Bhatnagar Award (2010).[3] She was also awarded the Wellcome Trust Flexible Travel Award grant by Stanford University for a Sabbatical year in 2008.[7] In 2014, Tole was awarded the Infosys Prize of 55 lakh rupees for her work elucidating the mechanisms and genes involved in the formation of the hippocampus.[3]
Publications edit
- LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11[8]
- Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus[9]
- Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes.[10]
References edit
- ^ Meet India's best scientist, Shubha Tole, Careers 360, archived from the original on 28 April 2017, retrieved 18 November 2015
- ^ Science of life, Mumbai Mirror, archived from the original on 4 March 2016, retrieved 17 November 2015
- ^ a b c d Infosys Prize, Infosys Science Foundation, archived from the original on 19 November 2015, retrieved 17 November 2015
- ^ Do not precompromise on your dreams: Dr.Shubha Tole, BioSpectrum, archived from the original on 19 November 2015, retrieved 17 November 2015
- ^ Shetty, Ashwin S.; Godbole, Geeta; Maheshwari, Upasana; Padmanabhan, Hari; Chaudhary, Rahul; et al. (21 November 2003). "Lhx2 regulates a cortex-specific mechanism for barrel formation". PNAS. 110 (50): E4913–E4921. doi:10.1073/pnas.1311158110. PMC 3864327. PMID 24262147.
- ^ String Duet, LiveMint, 8 February 2013, archived from the original on 19 November 2015, retrieved 18 November 2015
- ^ Shubha Tole, F1000 Prime, archived from the original on 19 November 2015, retrieved 18 November 2015
- ^ Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan SJ, Karmodiya K, Padmanabhan H, Shetty AS, Balaji C, Kolthur-Seetharam U, Macklis JD, Galande S, Tole S. .J Neurosci. 2017 Jan 4;37(1):194-203. doi: 10.1523/JNEUROSCI.2836-16.2016
- ^ Muralidharan B, Keruzore M, Pradhan SJ, Roy B, Shetty AS, Kinare V, D'Souza L, Maheshwari U, Karmodiya K, Suresh A, Galande S, Bellefroid EJ, Tole S. J Neurosci. 2017 Nov 15;37(46):11245-11254. doi: 10.1523/JNEUROSCI.1535-17.2017. Epub 2017 Oct 12. PMID 29025924
- ^ Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes. Godbole G, Roy A, Shetty AS, Tole S. Neural Dev. 2017 Nov 15;12(1):19. doi: 10.1186/s13064-017-0097-y.PMID 29141678
External links edit
- Jayan, T.V. (27 August 2007). "Snakes on ropes". The Telegraph
- Shubha Tole TIFR Profile