SC 42 may refer to:
- Convoy SC 42, a World War II transatlantic convoy of merchant ships
- USS SC-42, a United States Navy submarine chaser commissioned in 1918 and sold in 1921
- Scandium-42 (Sc-42 or 42Sc), an isotope of scandium
- South Carolina Highway 42 (1920s), a former state highway from Sumter to Bishopville
- South Carolina Highway 42 (1930s–1940s), a former state highway from northeast of Cope to Orangeburg
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