RTN3

Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.

RTN3
Identifiers
Aliases	RTN3, ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon 3
External IDs	OMIM: 604249 MGI: 1339970 HomoloGene: 24934 GeneCards: RTN3
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 63,681,446 bp End 63,759,891 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 7,403,266 bp End 7,460,646 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 prefrontal cortex ganglionic eminence pons hypothalamus amygdala cerebellar hemisphere nucleus accumbens substantia nigra caudate nucleus Top expressed in facial motor nucleus anterior horn of spinal cord primary motor cortex medial vestibular nucleus prefrontal cortex motor neuron dorsomedial hypothalamic nucleus medial dorsal nucleus Region I of hippocampus proper superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane Golgi membrane Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum membrane plasma membrane extracellular space synapse Biological process endoplasmic reticulum tubular network organization viral process vesicle-mediated transport apoptotic process endoplasmic reticulum tubular network formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10313 20168 Ensembl ENSG00000133318 ENSMUSG00000024758 UniProt O95197 Q9ES97 RefSeq (mRNA) NM_001265589 NM_001265590 NM_001265591 NM_006054 NM_201428 NM_201429 NM_201430 NM_001003930 NM_001003933 NM_001003934 NM_001271486 NM_001271487 NM_053076 RefSeq (protein) NP_001252518 NP_001252519 NP_001252520 NP_006045 NP_958831 NP_958832 NP_958833 NP_001003933 NP_001003934 NP_001258415 NP_001258416 NP_444306 Location (UCSC) Chr 11: 63.68 – 63.76 Mb Chr 19: 7.4 – 7.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Qu X, Qi Y, Qi B (2002). "Generation of multiple mRNA transcripts from the novel human apoptosis-inducing gene hap by alternative polyadenylation utilization and the translational activation function of 3' untranslated region". Arch. Biochem. Biophys. 400 (2): 233–44. doi:10.1016/S0003-9861(02)00016-4. PMID 12054434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Qi B, Qi Y, Watari A, et al. (2003). "Pro-apoptotic ASY/Nogo-B protein associates with ASYIP". J. Cell. Physiol. 196 (2): 312–8. doi:10.1002/jcp.10297. PMID 12811824. S2CID 7066102.
• Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family" (PDF). FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
• Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Huang X, Yang H, Zhou Y, et al. (2004). "Overexpression of human reticulon 3 (hRTN3) in astrocytoma". Clin. Neuropathol. 23 (1): 1–7. PMID 14986927.
• Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
• He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
• Di Scala F, Dupuis L, Gaiddon C, et al. (2005). "Tissue specificity and regulation of the N-terminal diversity of reticulon 3". Biochem. J. 385 (Pt 1): 125–34. doi:10.1042/BJ20040458. PMC 1134680. PMID 15350194.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gan M, Qi Y, Wan Q, et al. (2005). "Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death". Mol. Biol. Rep. 31 (3): 159–64. doi:10.1023/B:MOLE.0000043551.84883.c8. PMID 15560370. S2CID 11901566.
• Kuang E, Wan Q, Li X, et al. (2005). "ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP)". J. Cell. Physiol. 204 (2): 549–59. doi:10.1002/jcp.20340. PMID 15799019. S2CID 30086875.
• Cai Y, Saiyin H, Lin Q, et al. (2005). "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain". Brain Res. Mol. Brain Res. 138 (2): 236–43. doi:10.1016/j.molbrainres.2005.04.020. PMID 15946766.
• Wakana Y, Koyama S, Nakajima K, et al. (2005). "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi". Biochem. Biophys. Res. Commun. 334 (4): 1198–205. doi:10.1016/j.bbrc.2005.07.012. PMID 16054885.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ (2010). "Widespread Distribution of Reticulon-3 in Various Neurodegenerative Diseases". Neuropathology. 30 (6): 574–9. doi:10.1111/j.1440-1789.2010.01107.x. PMC 2902651. PMID 20374499.

External links

• RTN3 human gene location in the UCSC Genome Browser.
• RTN3 human gene details in the UCSC Genome Browser.