RNF122

RING finger protein 122 is a protein that in humans is encoded by the RNF122 gene.

RNF122
Identifiers
Aliases	RNF122, ring finger protein 122
External IDs	MGI: 1916117 HomoloGene: 11717 GeneCards: RNF122
Gene location (Human) Chr. Chromosome 8 (human) Band 8p12 Start 33,547,754 bp End 33,567,128 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A3 Start 31,601,848 bp End 31,621,510 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube ganglionic eminence gastrocnemius muscle right uterine tube upper lobe of left lung gastric mucosa gallbladder left ventricle right lung cerebellar cortex Top expressed in hand maxillary prominence superior cervical ganglion secondary oocyte ganglionic eminence foot medial ganglionic eminence neural tube otolith organ utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity metal ion binding protein binding Cellular component integral component of membrane Golgi apparatus membrane endoplasmic reticulum endomembrane system cytoplasm Biological process proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination protein ubiquitination negative regulation of mitochondrial membrane potential positive regulation of apoptotic process protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79845 68867 Ensembl ENSG00000133874 ENSMUSG00000039328 UniProt Q9H9V4 Q8BP31 RefSeq (mRNA) NM_024787 NM_175136 NM_001368373 NM_001368374 NM_001368375 RefSeq (protein) NP_079063 NP_780345 NP_001355302 NP_001355303 NP_001355304 Location (UCSC) Chr 8: 33.55 – 33.57 Mb Chr 8: 31.6 – 31.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.

Further reading

• Koyama K, Sudo K, Nakamura Y (1995). "Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification". Genomics. 26 (2): 245–53. doi:10.1016/0888-7543(95)80207-3. PMID 7601449.
• Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang L, Gao X, Gao P, et al. (2006). "Cell-based screening and validation of human novel genes associated with cell viability". Journal of Biomolecular Screening. 11 (4): 369–76. doi:10.1177/1087057106286654. PMID 16751333.
• Wang L, Shi TP, Wang L, et al. (2006). "[Cloning, expression and subcellular localization of a novel human gene-RNF122]". Beijing da Xue Xue Bao. 38 (3): 239–43. PMID 16778963.