A Price-Jones curve is a graph showing the distribution of diameters of red blood cells. Higher diameter may be seen in pernicious anaemia, while lower diameter may be seen after haemorrhage.
Medical uses edit
A Price-Jones curve can be used in the diagnosis of anaemia.[1][2] Price-Jones curves usually vary both by average red blood cell size, and the distribution of sizes.[3]
Interpretation of results edit
Higher red blood cell diameter and wider variation in size are often seen in pernicious anaemia.[3] Lower diameter with normal variation in size are often seen after haemorrhage.[3] A higher variation in size is known as anisocytosis.[4][5]
Procedure edit
A blood smear can be used to view individual red blood cells. The diameter of each red blood cell can be measured, which is usually analogous to volume.[2] This is usually performed automatically by particle counters.[2][4] Data is then converted into a histogram.[1] This can be used to assess red blood cell distribution width (RDW).[1][4]
History edit
Cecil Price-Jones first proposed using the Price-Jones curve in a 1922 paper.[6] It has been used for assessing red blood cells since then.[7]
References edit
- ^ a b c Sarma, P. Ravi (1990). "152 - Red Cell Indices". Clinical Methods: The History, Physical, and Laboratory Examinations (3rd ed.). ISBN 978-0-409-90077-4. PMID 21250103.
- ^ a b c McLaren, Christine E (June 1996). "Mixture models in haematology: a series of case studies". Statistical Methods in Medical Research. 5 (2): 129–153. doi:10.1177/096228029600500203. ISSN 0962-2802. PMID 8817795. S2CID 11124775.
- ^ a b c Evans, Timothy C.; Jehle, Dietrich (1991-01-01). "The red blood cell distribution width". The Journal of Emergency Medicine. 9: 71–74. doi:10.1016/0736-4679(91)90592-4. ISSN 0736-4679. PMID 1955687.
- ^ a b c Constantino, Benie T. (May 2013). "Red Cell Distribution Width, Revisited". Laboratory Medicine. 44 (2): e2–e9. doi:10.1309/LMZ1GKY9LQTVFBL7.
- ^ Choudhary, Sarita; Bordia, Sandhya; Choudhary, Kavita (December 2018). "Sensitivity of Red Cell Histogram and CBC parameters against Peripheral Blood Smear in Various Anemias" (PDF). Indian Journal of Basic and Applied Medical Research. 8 (1): 135–141.
- ^ Price-Jones, Cecil (1922). "The diameters of red cells in pernicious anaemia and in anaemia following haemorrhage" (PDF). The Journal of Pathology and Bacteriology. 25 (4): 487–504. doi:10.1002/path.1700250410.
- ^ Halie, M. R. (1985). "Aspects of quantitative cytometry: an overview". Pure and Applied Chemistry (in German). 57 (4): 587–592. doi:10.1351/pac198557040587. ISSN 1365-3075. S2CID 54866239.