April 16
- 1939 – Forty-five people were killed by tornadoes across Texas, Arkansas, and Louisiana. An F4 tornado killed 27 people in Drew County, Arkansas, including 11 in a church near Center Point that had just held a funeral service, and 9 on a single plantation. Another F4 tornado "swept away" a subdivision in Haynesville, Louisiana, killing 8 people.
- 1944 – Two F4 tornadoes struck Georgia and South Carolina, killing 41 people and injuring 320. The first killed 25 people along a 40 mi (64 km) track as moved through Royston and Montevideo, Georgia, and passed near Nuberg, Georgia and Ava, South Carolina. Five people died in one family in Royston. The second tornado killed 16 people, most of them in Abbeville and Greenwood, South Carolina. Most of the dead from this tornado were children.
- 2011 – The third and deadliest day of one of the largest tornado outbreaks on record impacted the Southeastern United States, resulting in 26 deaths. An EF3 tornado killed 12 people in Askewville, North Carolina out of a population of about 240. A long-track EF3 tornado six people in Sanford, North Carolina and Raleigh, North Carolina and moved directly through downtown Raleigh. Four children were killed when a tree fell on a mobile home.