- April 12, 1961 - Yuri Gagarin, aboard Vostok 1 becomes the first human in space.
- April 12, 1981 - First flight of the Space Shuttle.
- April 12, 1985 - Jake Garn becomes the first politician in space.
- April 14, 1970 - An oxygen tank explodes onboard Apollo 13.
- April 23, 1967 - Vladimir Komarov becomes the first fatality during spaceflight when Soyuz 1 fails on reentry.
- April 24, 1990 - Hubble Space Telescope launched aboard the Space Shuttle.
- April 29, 2001 - Dennis Tito becomes the first space tourist.
