January – February – March – April – May – June – July – August – September – October – November – December
- November 1, 1912 - Birth of Alicia Moreda, television soap opera actress (d. 1983)
- November 1, 1950 - Two Puerto Rican nationalists try to storm the Blair House in a failed attempt to assassinate U.S. President Harry S. Truman.
- November 1, 1963 - The Arecibo Observatory, the largest single-aperture telescope, officially opened for operations.
- November 1, 1927 - Birth of Victor Pellot, former Mayor League Baseball player
- November 2, 2004 - General elections were held in Puerto Rico, with no clear victor for the Governor seat. On December 28, Aníbal Acevedo Vilá was declared the winner following several recounts and court rulings.
- November 3, 1867 - Death of Segundo Ruiz Belvis, abolitionist and political activist (b. 1829)
- November 5, 1934 - Birth of Victor Argo, actor (d. 2004)
- November 6, 1958 - The Puerto Rico Symphony Orchestra performs in its first live concert in Mayagüez.
- November 7, 1944 - General elections were held in Puerto Rico. The Popular Democratic Party won by a landslide.
- November 7, 1944 - 16 passengers lost their lives and 50 were injured when a train derailed in Aguadilla, making it the worst disaster in Puerto Rico rail transport history.
- November 9, 1945 - The 65th Infantry arrive in Puerto Rico after their participation in World War II.
- November 16, 1952 - Death of Jesús T. Piñero, first native Governor of Puerto Rico (b. 1897)
- November 19, 1493 - Christopher Columbus discovers Puerto Rico, naming the island San Juan Bautista in honor of Saint John the Baptist. The day has since become a national holiday on the island.
- November 19, 1982 - Birth of Jonathan Sánchez, Mayor League Baseball pitcher
- November 20, 1878 - Birth of Félix Córdova Dávila, politician and Resident Commissioner of Puerto Rico (d. 1938)
- November 22, 1595 - Sir Francis Drake, with 27 vessels and 2,500 troops, sails into San Juan Bay in an attempt to loot the city. His attack would ultimately fail.
- November 25, 1897 - The Carta Autonómica (Autonomic Charter) was approved in Spain, which conceded political and administrative autonomy to the island.
- November 29, 2005 - Death of Victor Pellot, as a result of cancer
- November 30, 1971 - Birth of Iván Rodríguez, Mayor League Baseball catcher