- 1 April 1997 – Comet Hale-Bopp at perihelion
- 12 April 1633 – Galileo Galilei's trial starts
- 15 April 1707 – Leonhard Euler's birthday
- 18 April 1955 – Albert Einstein's death
- 22 April 1904 – J. Robert Oppenheimer's birthday
- 23 April 1858 – Max Planck's birthday
- 24 April 1990 – Hubble Space Telescope launched
- 25 April 1990 – Hubble Space Telescope deployed from the shuttle Discovery
- 30 April 1777 – Carl Friedrich Gauss's birthday
