- April 3, 1983 - The Lucanamarca massacre took place in which 69 peasants were killed by the Shining Path organization in and around the town of Lucanamarca.
- April 12, 1671 - Pope Clement IX canonized Rose of Lima, making her the first Roman Catholic saint in the Western Hemisphere.
- April 22, 1997 - The Japanese embassy hostage crisis ended when Peruvian armed forces raided the official residence of Japan's ambassador to Peru in Lima and killed all Túpac Amaru Revolutionary Movement (MRTA) militants.
- April 26, 1538 - Two rival Spanish military forces engaged in the Battle of Las Salinas near Cusco. Pizarro's forces defeated those of rival conquistador Diego de Almagro.
- April 28, 1947 - Thor Heyerdahl set sail from Peru with his ship the Kon-Tiki to finally reach the Tuamotu Archipelago after 101 days and 4,300 miles at sea.
- April 30, 1932 - Start of the Colombia–Peru War an armed conflict with Colombia concerning a long-standing border dispute in the Amazonas region.