February 26 to March 4, 2006 edit
- February 26: New York Giants safety Brent Alexander retires.
- February 24: The Chicago Bears signed lineman John St. Clair for three years.
- February 24: The Indianapolis Colts signed defensive lineman Raheem Brock for five years.
March 4 to April 4, 2006 edit
- March 4: the Chicago Bears sign guard Terrence Metcalf for six years.
- March 3: the Pittsburgh Steelers release former starting quarterback Tommy Maddox and cornerback Willie Williams for salary cap reasons.
- March 3: the Cleveland Browns resign running back Reuben Droughns for three years and $1.5 million.
April 4 to May 28, 2006 edit
- April 4: The Buffalo Bills trade Eric Moulds to the Houston Texans. Moulds agrees to a four-year contract.
- April 4: Daunte Culpepper is cleared of misdemeanor charges stemming from a party boat scandal.
- March 31: The Cincinnati Bengals sign Sam Adams to a three-year contract.