Polyaminopropyl biguanide (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses.[citation needed] It is also an ingredient in many deodorant bodysprays.[citation needed] It is a polymer or oligomer where biguanide functional groups are connected by propyl hydrocarbon chains. PAPB is specifically bactericidal at very low concentrations (10 mg/L) and is also fungicidal.[citation needed]
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| Names | |
|---|---|
| Other names
Polyamine-propyl-biguanidine
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| Identifiers | |
| Abbreviations | PAPB |
| ChemSpider |
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| ECHA InfoCard | 100.118.649 |
| UNII | |
| Properties | |
| (C5H11N5)n | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Biocidal activity edit
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[citation needed]
Disinfectant edit
PAPB solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[citation needed] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).
Contact lens solution edit
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[citation needed]