Plexin A1

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.

PLXNA1
Identifiers
Aliases	PLXNA1, NOV, NOVP, PLEXIN-A1, PLXN1, Plexin A1
External IDs	OMIM: 601055 MGI: 107685 HomoloGene: 56426 GeneCards: PLXNA1
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.3 Start 126,982,693 bp End 127,037,389 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 89,293,296 bp End 89,339,602 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus stromal cell of endometrium Brodmann area 23 endothelial cell sural nerve Brodmann area 46 superior frontal gyrus Region I of hippocampus proper orbitofrontal cortex entorhinal cortex Top expressed in bronchus lobar bronchus lip ascending aorta secondary oocyte internal carotid artery molar aortic valve external carotid artery cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function semaphorin receptor activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular exosome integral component of plasma membrane Biological process regulation of axon extension involved in axon guidance neuron projection extension multicellular organism development neuron projection guidance branchiomotor neuron axon guidance dichotomous subdivision of terminal units involved in salivary gland branching regulation of smooth muscle cell migration semaphorin-plexin signaling pathway signal transduction negative regulation of cell adhesion regulation of cell shape regulation of cell migration regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5361 18844 Ensembl ENSG00000114554 ENSMUSG00000030084 UniProt Q9UIW2 P70206 RefSeq (mRNA) NM_032242 NM_008881 RefSeq (protein) NP_115618 NP_032907 Location (UCSC) Chr 3: 126.98 – 127.04 Mb Chr 6: 89.29 – 89.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Plexin A1 has been shown to interact with AKT1.

Further reading

• Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. doi:10.1016/S0092-8674(00)80062-8. PMID 10520994. S2CID 18167425.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
• Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845. S2CID 7914214.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433. S2CID 2487482.
• Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682. PMID 11784792.
• Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
• Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells". Cancer Res. 63 (17): 5230–3. PMID 14500350.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMC 359397. PMID 14977921.
• Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. PMID 15187088.
• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.