Peroxyureidoacrylate/ureidoacrylate amidohydrolase (EC 3.5.1.110, RutB) is an enzyme with systematic name (Z)-3-ureidoacrylate peracid amidohydrolase.[1] This enzyme catalyses the following chemical reaction sequences:
- (Z)-3-ureidoacrylate peracid + H2O ⇌ (Z)-3-peroxyaminoacrylate + CO2 + NH3 (overall reaction)
- (Z)-3-ureidoacrylate peracid + H2O ⇌ (Z)-3-peroxyaminoacrylate + carbamate
- carbamate ⇌ CO2 + NH3 (spontaneous)
- (Z)-2-methylureidoacrylate peracid + H2O ⇌ (Z)-2-methylperoxyaminoacrylate + CO2 + NH3 (overall reaction)
- (Z)-2-methylureidoacrylate peracid + H2O ⇌ (Z)-2-methylperoxyaminoacrylate + carbamate
- carbamate ⇌ CO2 + NH3 (spontaneous)
| Peroxyureidoacrylate/ureidoacrylate amidohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.110 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme also shows activity towards ureidoacrylate.
References edit
- ^ Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE (August 2010). "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems". Journal of Bacteriology. 192 (16): 4089–102. doi:10.1128/JB.00201-10. PMC 2916427. PMID 20400551.
External links edit
- Peroxyureidoacrylate/ureidoacrylate+amidohydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
