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Pauline Schaap is a Dutch cell biologist and evolutionary biologist. She is Professor of Developmental Signalling at the University of Dundee.,[1] a corresponding member of the Royal Netherlands Academy of Arts and Sciences, a Fellow of the Royal Society of Biology, and a Fellow of the Royal Society of Edinburgh.
She studies the evolution of multicellularity and cell differentiation in social amoebae.[2]
Biography edit
Schaap received her PhD in 1987 from the University of Leiden.[3] She was a professor at the University of Leiden until 1999, when she moved to the University of Dundee[4] where she is currently a professor.[1] She became a corresponding member of the Royal Netherlands Academy of Arts and Sciences in 2011.[4][5]
Professional contributions edit
Schaap and her collaborators established the first molecular phylogeny of the Dictyostelia.[6] That work showed that complex multicellular fruiting bodies had evolved multiple times independently, contrary to what had previously been generally thought.[6] More recently, Schaap and her team showed that the molecular pathway for multicellular development in dictyostelids had evolved from an ancestral encystment pathway present in single-celled amoebae,[7][8][9] thus contributing to elucidating the molecular basis for the evolution of multicellularity [10]
References edit
- ^ a b PSchaap (30 August 2013). "Professor Pauline Schaap FRSE FRSB". School of Life Sciences. Retrieved 7 May 2020.
- ^ Schaap, Pauline (1 February 2011). "Evolutionary crossroads in developmental biology: Dictyostelium discoideum". Development. 138 (3): 387–396. doi:10.1242/dev.048934. ISSN 0950-1991. PMC 3014629. PMID 21205784.
- ^ "Pauline Schaap - AcademiaNet". www.academia-net.org. Retrieved 7 May 2020.
- ^ a b "Professor Pauline Schaap FRSE". The Royal Society of Edinburgh. 24 March 2020. Retrieved 7 May 2020.
- ^ "Pauline Schaap". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 9 May 2020.
- ^ a b Schaap, Pauline; Winckler, Thomas; Nelson, Michaela; Alvarez-Curto, Elisa; Elgie, Barrie; Hagiwara, Hiromitsu; Cavender, James; Milano-Curto, Alicia; Rozen, Daniel E.; Dingermann, Theodor; Mutzel, Rupert (27 October 2006). "Molecular Phylogeny and Evolution of Morphology in the Social Amoebas". Science. 314 (5799): 661–663. Bibcode:2006Sci...314..661S. doi:10.1126/science.1130670. ISSN 0036-8075. PMC 2173941. PMID 17068267.
- ^ Kawabe, Yoshinori; Schilde, Christina; Du, Qingyou; Schaap, Pauline (16 April 2015). "A Conserved Signalling Pathway for Amoebozoan Encystation that was Co-Opted for Multicellular Development". Scientific Reports. 5 (1): 9644. Bibcode:2015NatSR...5E9644K. doi:10.1038/srep09644. ISSN 2045-2322. PMC 4399386. PMID 25881075.
- ^ Schaap, Pauline (1 August 2016). "Evolution of developmental signalling in Dictyostelid social amoebas". Current Opinion in Genetics & Development. Developmental mechanisms, patterning and evolution. 39: 29–34. doi:10.1016/j.gde.2016.05.014. ISSN 0959-437X. PMC 5113120. PMID 27318097.
- ^ Kawabe, Yoshinori; Morio, Takahiro; Tanaka, Yoshimasa; Schaap, Pauline (9 May 2018). "Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia". EvoDevo. 9 (1): 12. doi:10.1186/s13227-018-0101-6. ISSN 2041-9139. PMC 5941370. PMID 29760875.
- ^ Brunet, Thibaut; King, Nicole (23 October 2017). "The Origin of Animal Multicellularity and Cell Differentiation". Developmental Cell. 43 (2): 124–140. doi:10.1016/j.devcel.2017.09.016. ISSN 1534-5807. PMC 6089241. PMID 29065305.