PWP2

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.

PWP2
Identifiers
Aliases	PWP2, EHOC-17, PWP2H, UTP1, PWP2 periodic tryptophan protein homolog (yeast), small subunit processome component, PWP2 small subunit processome component
External IDs	OMIM: 601475 MGI: 1341200 HomoloGene: 136786 GeneCards: PWP2
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.3 Start 44,107,373 bp End 44,131,181 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 39.72 cM Start 78,006,743 bp End 78,020,983 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium corpus callosum gastric mucosa skeletal muscle tissue sural nerve prefrontal cortex right adrenal gland blood Achilles tendon spleen Top expressed in primitive streak secondary oocyte otic placode cumulus cell yolk sac morula saccule hair follicle maxillary prominence supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function snoRNA binding RNA binding Cellular component Pwp2p-containing subcomplex of 90S preribosome nucleus nucleolus small-subunit processome nucleoplasm Biological process ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5822 110816 Ensembl ENSG00000241945 ENSMUSG00000032834 UniProt Q15269 Q8BU03 RefSeq (mRNA) NM_005049 NM_029546 RefSeq (protein) NP_005040 NP_083822 Location (UCSC) Chr 21: 44.11 – 44.13 Mb Chr 10: 78.01 – 78.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This protein is involved in the assembly of small subunit of ribosome.

Further reading

• Lalioti MD, Chen H, Rossier C, et al. (1996). "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3". Genomics. 35 (2): 321–7. doi:10.1006/geno.1996.0363. PMID 8661145.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Lafrenière RG, Rochefort DL, Chrétien N, et al. (1997). "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3". Genome Res. 6 (12): 1216–26. doi:10.1101/gr.6.12.1216. PMID 8973917.
• Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. doi:10.1006/bbrc.1997.6758. PMID 9196060.
• Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.