PRMT3

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.

PRMT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Aliases	PRMT3, HRMT1L3, protein arginine methyltransferase 3
External IDs	OMIM: 603190 MGI: 1919224 HomoloGene: 24255 GeneCards: PRMT3
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 20,387,558 bp End 20,509,338 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B4 Start 49,428,094 bp End 49,508,013 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle left lobe of thyroid gland germinal epithelium right lobe of thyroid gland islet of Langerhans left adrenal gland palpebral conjunctiva stromal cell of endometrium ganglionic eminence Top expressed in condyle cumulus cell fossa substantia nigra Paneth cell primitive streak motor neuron medial ganglionic eminence abdominal wall hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding methyltransferase activity transferase activity protein binding protein-arginine N-methyltransferase activity nucleic acid binding histone-arginine N-methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity ribosome binding Cellular component ribosome cytoplasm cytosol nucleus Biological process methylation negative regulation of protein ubiquitination peptidyl-arginine N-methylation protein methylation regulation of transcription, DNA-templated peptidyl-arginine methylation, to asymmetrical-dimethyl arginine histone arginine methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10196 71974 Ensembl ENSG00000185238 ENSMUSG00000030505 UniProt O60678 Q922H1 RefSeq (mRNA) NM_001145166 NM_001145167 NM_005788 NM_133740 RefSeq (protein) NP_001138638 NP_001138639 NP_005779 NP_598501 Location (UCSC) Chr 11: 20.39 – 20.51 Mb Chr 7: 49.43 – 49.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PRMT3 has been shown to interact with RPS2.

Further reading

• Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, et al. (October 2004). "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo". Oncogene. 23 (47): 7761–71. doi:10.1038/sj.onc.1208057. PMID 15334060.
• Bachand F, Silver PA (July 2004). "PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits". The EMBO Journal. 23 (13): 2641–50. doi:10.1038/sj.emboj.7600265. PMC 449775. PMID 15175657.
• Smith JJ, Rücknagel KP, Schierhorn A, Tang J, Nemeth A, Linder M, et al. (May 1999). "Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3". The Journal of Biological Chemistry. 274 (19): 13229–34. doi:10.1074/jbc.274.19.13229. PMID 10224081.

External links

• PRMT3 human gene location in the UCSC Genome Browser.
• PRMT3 human gene details in the UCSC Genome Browser.