Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene .[5] [6]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[6]
Interactions
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References
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^ a b c GRCh38: Ensembl release 89: ENSG00000100227 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041815 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen" . J Biol Chem . 278 (12): 10041–7. doi :10.1074/jbc.M208694200 PMID 12522211 . ^ a b "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3" .^ Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control" . Curr. Biol . 14 (17). England: 1540–9. Bibcode :2004CBio...14.1540R . doi :10.1016/j.cub.2004.08.061 ISSN 0960-9822 . PMID 15341740 .
Further reading
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Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res . 8 (1): 1–9. CiteSeerX 10.1.1.321.2497 doi :10.1093/dnares/8.1.1 . PMID 11258795 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22" . Genome Res . 13 (1): 27–36. doi :10.1101/gr.695703 . PMC 430954 PMID 12529303 . Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control" . Curr. Biol . 14 (17): 1540–9. Bibcode :2004CBio...14.1540R . doi :10.1016/j.cub.2004.08.061 PMID 15341740 . Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 PMC 545604 PMID 15461802 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth" . FEBS J . 273 (20): 4728–41. doi :10.1111/j.1742-4658.2006.05477.x PMID 16984396 .
