OSBPL8

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

OSBPL8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V88
Identifiers
Aliases	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDs	OMIM: 606736 MGI: 2443807 HomoloGene: 68813 GeneCards: OSBPL8
Gene location (Human) Chr. Chromosome 12 (human) Band 12q21.2 Start 76,351,797 bp End 76,559,809 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D1 Start 111,000,613 bp End 111,133,110 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung lactiferous duct trabecular bone endothelial cell nipple Achilles tendon visceral pleura trigeminal ganglion superficial temporal artery external globus pallidus Top expressed in olfactory tubercle nucleus accumbens secondary oocyte cumulus cell olfactory epithelium myocardium of ventricle retinal pigment epithelium interventricular septum aortic valve hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylserine binding cholesterol binding phosphatidylinositol-4-phosphate binding lipid binding phospholipid transporter activity sterol transporter activity sterol binding Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane cortical endoplasmic reticulum endoplasmic reticulum nucleus cytosol intracellular membrane-bounded organelle Biological process activation of protein kinase B activity positive regulation of protein kinase B signaling lipid transport protein localization to nuclear pore phospholipid transport negative regulation of cell migration negative regulation of sequestering of triglyceride positive regulation of insulin receptor signaling pathway fat cell differentiation phosphatidylserine acyl-chain remodeling transport sterol transport positive regulation of glucose import Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114882 237542 Ensembl ENSG00000091039 ENSMUSG00000020189 UniProt Q9BZF1 B9EJ86 RefSeq (mRNA) NM_001003712 NM_020841 NM_001319652 NM_001319653 NM_001319655 NM_001003717 NM_175489 RefSeq (protein) NP_001003712 NP_001306581 NP_001306582 NP_001306584 NP_065892 NP_001003717 NP_780698 Location (UCSC) Chr 12: 76.35 – 76.56 Mb Chr 10: 111 – 111.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.