OPCA may refer to:
- Office of Public and Congressional Affairs, a part of the US Federal Bureau of Investigation
- Olivopontocerebellar atrophy, a brain disorder
- Orange Park Christian Academy, Orange Park, Florida, U.S.
- Organised pseudolegal commercial arguments, a type of pseudolaw
- Outer membrane protein OpcA
This disambiguation page lists articles associated with the title OPCA.
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