- Cornelius Nepos, the Roman biographer
- Julius Nepos, sometimes considered the last Emperor of the Western Roman Empire
- Aulus Platorius Nepos, the governor of Britannia under Hadrian
- Nepos (Roman governor), during the reign of the emperor Trajan
- The apocryphal Book of Nepos, written by an Egyptian bishop of the same name
- Nepos, a village in Feldru Commune, Bistriţa-Năsăud County, Romania
- Saint Nepos, a martyr and companion of the African Saint Quirinus]]
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