NDFIP1

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene.

NDFIP1
Identifiers
Aliases	NDFIP1, N4WBP5, Nedd4 family interacting protein 1
External IDs	OMIM: 612050; MGI: 1929601; HomoloGene: 12730; GeneCards: NDFIP1; OMA:NDFIP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.3 Start 142,108,779 bp End 142,154,440 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B3 Start 38,543,449 bp End 38,598,356 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell pons middle temporal gyrus superior frontal gyrus entorhinal cortex postcentral gyrus spinal ganglia corpus epididymis superior vestibular nucleus Top expressed in cingulate gyrus medial dorsal nucleus mammillary body ventral tegmental area dorsomedial hypothalamic nucleus ventromedial nucleus median eminence seminal vesicula paraventricular nucleus of hypothalamus dorsal tegmental nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity protein binding WW domain binding Cellular component integral component of membrane endosome membrane Golgi membrane extracellular region cell cortex perinuclear region of cytoplasm endosome membrane cell junction dendrite cell projection neuron projection synapse Golgi apparatus Biological process regulation of myeloid leukocyte differentiation regulation of isotype switching to IgG isotypes positive regulation of protein catabolic process negative regulation of interleukin-4 production metal ion transport negative regulation of isotype switching to IgE isotypes negative regulation of gene expression negative regulation of T cell proliferation regulation of lymphocyte differentiation negative regulation of protein transport negative regulation of type 2 immune response positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein ubiquitination negative regulation of inflammatory response negative regulation of transporter activity vacuolar transport cellular iron ion homeostasis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80762 65113 Ensembl ENSG00000131507 ENSMUSG00000024425 UniProt Q9BT67 Q8R0W6 RefSeq (mRNA) NM_030571 NM_022996 NM_001355749 RefSeq (protein) NP_085048 NP_075372 NP_001342678 Location (UCSC) Chr 5: 142.11 – 142.15 Mb Chr 18: 38.54 – 38.6 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].

Further reading

• Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS (2008). "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins". J. Biol. Chem. 283 (47): 32621–7. doi:10.1074/jbc.M804120200. PMID 18819914.
• Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
• Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. Bibcode:2009PNAS..10615489H. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
• Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. Bibcode:2010PNAS..10711429M. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
• Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
• Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
• Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLOS ONE. 9 (1): e87119. Bibcode:2014PLoSO...987119H. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
• Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
• Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.