NAD(P)H-hydrate epimerase (EC 5.1.99.6, NAD(P)HX epimerase) is an enzyme with systematic name (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase.[1] This enzyme catalyses the following chemical reaction
| NAD(P)H-hydrate epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.1.99.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
- (2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.
References edit
- ^ Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL (December 2011). "Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair". The Journal of Biological Chemistry. 286 (48): 41246–52. doi:10.1074/jbc.c111.310847. PMC 3308837. PMID 21994945.
External links edit
- NAD(P)H-hydrate+epimerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
