In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-592 | |
|---|---|
| Identifiers | |
| Symbol | mir-592 |
| Rfam | RF00877 |
| miRBase family | MIPF0000340 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Expression in cancers edit
Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer.[1] Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change.[2] This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states.
miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.
See also edit
References edit
- ^ Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, et al. (2009). "Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states". BMC Cancer. 9: 401. doi:10.1186/1471-2407-9-401. PMC 2787532. PMID 19922656.
- ^ Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, et al. (2011). "miRNA expression in colon polyps provides evidence for a multihit model of colon cancer". PLOS ONE. 6 (6): e20465. Bibcode:2011PLoSO...620465O. doi:10.1371/journal.pone.0020465. PMC 3111419. PMID 21694772.
Further reading edit
- Wang, W.; Zhao, L. -J.; Tan, Y. -X.; Ren, H.; Qi, Z. -T. (2012). "MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma". Carcinogenesis. 33 (5): 1113–1120. doi:10.1093/carcin/bgs113. PMC 3334515. PMID 22362728.
External links edit
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