Mex-3 homolog D (C. elegans) , also known as MEX3D , is a protein that in humans is encoded by the MEX3D gene .[5] [6]
Function
edit
MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2 . Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[6]
Structure
edit
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[6]
References
edit
^ a b c GRCh38: Ensembl release 89: ENSG00000181588 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048696 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: mex-3 homolog D (C. elegans)" .^ a b c Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein" . J. Biol. Chem . 279 (19): 20154–66. doi :10.1074/jbc.M314071200 PMID 14769789 .
Further reading
edit
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies" . Nucleic Acids Res . 35 (4): 1289–300. doi :10.1093/nar/gkm016 . PMC 1851655 PMID 17267406 .
