Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene .[5] [6]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[6]
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Further reading
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Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology" . Mol. Cell . 14 (5): 685–91. doi :10.1016/j.molcel.2004.05.006 PMID 15175163 . Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2" . J. Biol. Chem . 279 (7): 5846–51. doi :10.1074/jbc.M312523200 PMID 14638676 . Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex" . J. Biol. Chem . 278 (50): 49671–4. doi :10.1074/jbc.C300444200 PMID 14576168 . Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" . J. Biol. Chem . 278 (17): 15123–7. doi :10.1074/jbc.C300054200 PMID 12584197 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP" . Proc. Natl. Acad. Sci. U.S.A . 96 (13): 7137–42. Bibcode :1999PNAS...96.7137R . doi :10.1073/pnas.96.13.7137 PMC 22029 PMID 10377381 . Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature . 398 (6730): 828–32. Bibcode :1999Natur.398..828N . doi :10.1038/19789 . PMID 10235267 . S2CID 23646963 . Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways" . Proc. Natl. Acad. Sci. U.S.A . 95 (15): 8538–43. Bibcode :1998PNAS...95.8538J . doi :10.1073/pnas.95.15.8538 PMC 21111 PMID 9671713 . Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain" . Genes Dev . 12 (1): 45–54. doi :10.1101/gad.12.1.45 . PMC 316402 PMID 9420330 .
