MED18

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

MED18
Identifiers
Aliases	MED18, p28b, mediator complex subunit 18, SRB5
External IDs	OMIM: 612384 MGI: 1914469 HomoloGene: 9756 GeneCards: MED18
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.3 Start 28,329,002 bp End 28,335,965 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.3 Start 132,186,042 bp End 132,191,232 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium lymph node blood rectum skeletal muscle tissue duodenum appendix liver monocyte Top expressed in Region I of hippocampus proper hand maxillary prominence globus pallidus intercostal muscle internal carotid artery parotid gland external carotid artery molar foot More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component core mediator complex mediator complex nucleus ubiquitin ligase complex Biological process regulation of transcription by RNA polymerase II termination of RNA polymerase II transcription regulation of transcription, DNA-templated transcription, DNA-templated protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54797 67219 Ensembl ENSG00000130772 ENSG00000284944 ENSMUSG00000066042 UniProt Q9BUE0 Q9CZ82 RefSeq (mRNA) NM_001127350 NM_017638 NM_026039 RefSeq (protein) NP_001120822 NP_060108 NP_080315 Location (UCSC) Chr 1: 28.33 – 28.34 Mb Chr 4: 132.19 – 132.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.

See also

• Mediator

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.