This is a list of films which have placed number one at the weekly box office in Italy during 2012.
| # | Date | Film | Total Gross | Notes |
|---|---|---|---|---|
| 1 | January 8, 2012 | Immaturi - Il viaggio | $15,512,578 | |
| 2 | January 15, 2012 | Immaturi - Il viaggio | ||
| 3 | January 22, 2012 | Benvenuti al Nord | $33,498,625 | |
| 4 | January 29, 2012 | Benvenuti al Nord | ||
| 5 | February 5, 2012 | Benvenuti al Nord | ||
| 6 | February 12, 2012 | Com'è bello far l'amore | $9,065,716 | |
| 7 | February 19, 2012 | Com'è bello far l'amore | ||
| 8 | February 26, 2012 | Journey 2: The Mysterious Island | $5,908,558 | |
| 9 | March 4, 2012 | A Flat for Three | $11,398,541 | |
| 10 | March 11, 2012 | A Flat for Three | ||
| 11 | March 18, 2012 | The Intouchables | $19,385,193 | |
| 12 | March 25, 2012 | Ghost Rider: Spirit of Vengeance | $3,731,609 | |
| 13 | April 1, 2012 | Wrath of the Titans | $5,447,003 | |
| 14 | April 8, 2012 | Titanic 3D | $9,847,064 | |
| 15 | April 15, 2012 | Battleship | $5,747,869 | |
| 16 | April 22, 2012 | To Rome with Love | $9,565,012 | |
| 17 | April 29, 2012 | Marvel's The Avengers | $22,012,517 | |
| 18 | May 6, 2012 | American Reunion | $7,878,279 | |
| 19 | May 13, 2012 | Dark Shadows | $8,830,490 | |
| 20 | May 20, 2012 | Dark Shadows | ||
| 21 | May 27, 2012 | Men in Black 3 | $7,671,850 | |
| 22 | June 3, 2012 | Men in Black 3 | ||
| 23 | June 10, 2012 | Men in Black 3 | ||
| 24 | June 17, 2012 | The Dictator | $3,337,936 | |
| 25 | June 24, 2012 | The Dictator | ||
| 26 | July 1, 2012 | The Dictator | ||
| 27 | July 8, 2012 | The Amazing Spider-Man | $15,502,063 | |
| 28 | July 15, 2012 | Snow White and the Huntsman | $11,463,994 | |
| 29 | July 22, 2012 | Snow White and the Huntsman | ||
| 30 | July 29, 2012 | Snow White and the Huntsman | ||
| 31 | August 5, 2012 | Snow White and the Huntsman | ||
| 32 | August 12, 2012 | Snow White and the Huntsman | ||
| 33 | August 19, 2012 | The Expendables 2 | $7,082,046 | |
| 34 | August 26, 2012 | Madagascar 3: Europe's Most Wanted | $28,057,921 | |
| 35 | September 2, 2012 | Madagascar 3: Europe's Most Wanted | ||
| 36 | September 9, 2012 | The Dark Knight Rises | $18,801,748 | |
| 37 | September 16, 2012 | Prometheus | $6,499,130 | |
| 38 | September 23, 2012 | Magic Mike | $5,032,03 | |
| 39 | September 30, 2012 | Ice Age: Continental Drift | $21,459,516 | |
| 40 | October 7, 2012 | Ice Age: Continental Drift | ||
| 41 | October 14, 2012 | Ted | $14,054,547 | |
| 42 | October 21, 2012 | Ted | ||
| 43 | October 28, 2012 | Viva L'Italia | $6,880,371 | |
| 44 | November 4, 2012 | Skyfall | $16,783,632 | |
| 45 | November 11, 2012 | Skyfall | ||
| 46 | November 18, 2012 | The Twilight Saga: Breaking Dawn - Part 2 | $24,062,547 | |
| 47 | November 25, 2012 | The Twilight Saga: Breaking Dawn Part 2 | ||
| 48 | December 2, 2012 | Rise of the Guardians | $5,788,535 | |
| 49 | December 9, 2012 | Rise of the Guardians | ||
| 50 | December 16, 2012 | The Hobbit: An Unexpected Journey | $10,666,115 |