George grew up in Grimsby, Lincolnshire with her construction manager father, her mother and older sister. She had wanted to be an actress since the age of twelve and had lead roles in many school productions. Following her school career she trained at the Royal Welsh College of Music and Drama.
In 1997 George toured with a stage musical version of Prisoner: Cell Block H. Her television credits include a role in the 2003 BAFTA nominated television adaptation of the Jaqueline Wilson novel The Illustrated Mum as well as episodes of British serial dramas Casualty, Holby City and Emmerdale. In 2005 she appeared as a soul singer in an advertisement for fast food restaurant KFC.. To date, she has had four different roles in Coronation Street. In 1997 she played a nursing colleague of regular character Martin Platt and appeared in five episodes in 2005 as a police family liaison officer. She was cast as the character Beth Tinker, a former model and ex-girlfriend of Steve McDonald, in two episodes of the serial which aired in August 2011. The production team later brought Tinker back as a permanent character. For her role as Beth, George has been nominated as Best Newcomer in the 2012 annual TV Choice Awards. The actress stated she was "shocked and over the moon" to be nominated for the award. In May 2012 George took on a role as leader of the 'Cheer Squad' to support runners participating in the 2012 Great Manchester Run in aid of Diabetes UK.
- "Lisa George - Spotlight Actresses 2011/2012". Retrieved 28 May 2012.
- Millar, Paul (25 May 2012). "'Coronation Street' Lisa George "chuffed to bits" with TV Choice nod". Digital Spy. Retrieved 27 May 2012.
- "Stars to support Manchester run". Stamford Mercury. 19 May 2012. Retrieved 27 May 2012.