Kuwano (written: 桑野) is a Japanese surname. Notable people with the surname include:

  • Hijiri Kuwano (桑野 聖, born 1964), Japanese violinist, composer and arranger
  • Michiko Kuwano (桑野 通子, 1915–1946), Japanese actress
  • Nobuyoshi Kuwano (桑野 信義, born 1957), Japanese television performer

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