Kalamurina Sanctuary is a 6,700 km2pastoral lease in arid north-eastern South Australia. For many decades in the 20th century it operated as a cattle station. It was acquired in December 2007 by the Australian Wildlife Conservancy to become a nature reserve for biodiversity conservation and wildlife management. A high priority management need is a feral animal control program.
Lying between the Simpson Desert Regional Reserve and the Lake Eyre National Park, the establishment of Kalamurina as a nature reserve creates a continuous protected area in central Australia larger than the State of Tasmania.