KPNO may refer to:
- Kitt Peak National Observatory, astronomical observatory in Arizona
- KPNO (FM), a Christian radio station in Norfolk, Nebraska, repeating the signal from KGRD in Orchard, Nebraska
- K-Pop Night Out at SXSW, original name of Korea Spotlight, an annual concert of South Korean artists held in the United States
This disambiguation page lists articles associated with the title KPNO.
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