Jefferson Hotel or Hotel Jefferson may refer to:
- Jefferson Hotel (Shreveport, Louisiana), listed on the National Register of Historic Places (NRHP)
- Hotel Jefferson (St. Louis, Missouri), NRHP-listed
- Jefferson Hotel (Jefferson, Texas), asserted to have been built in 1851, subject of a My Ghost Story episode (and if it is the hotel known as "Excelsior House", is NRHP-listed as an element of Jefferson Historic District (Jefferson, Texas))
- Jefferson Hotel (Richmond, Virginia), NRHP-listed
- The Jefferson, a hotel in Washington, D.C.
This disambiguation page lists articles associated with the title Jefferson Hotel.
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