Izzo is an Italian surname. Notable people with the surname include:

  • Angelo Izzo, Italian pharmacologist
  • Armando Izzo (born 1992), Italian footballer
  • Jean-Claude Izzo (1945–2000), French poet, playwright, screenwriter, and novelist
  • John Izzo, American and Canadian businessman, corporate advisor, speaker, bestselling author and an advocate for sustainable living
  • Larry Izzo (born 1974), American football player
  • Lorenza Izzo (born 1989), Chilean film actress and model
  • Paul Izzo (born 1995), Australian professional football player
  • Renato Izzo (1929-2009), Italian actor, voice actor and screenwriter
  • Ryan Izzo (born 1995), American football player
  • Simona Izzo (born 1953), Italian actress, voice actress, director and screenwriter
  • Tom Izzo (born 1955), American college basketball coach