|Classification and external resources|
Micrograph of dermatomyositis, a type of inflammatory myopathy. Muscle biopsy. H&E stain.
Inflammatory myopathy is a form of myopathy that involves inflammation of the muscle.
Inflammatory myopathy is generally synonymous to the term dermatopolymyositis, which, according to ICD-10 encompasses three related diseases: polymyositis, dermatomyositis, and inclusion-body myositis.
Dermatopolymyositis can be associated with several types of autoantibodies:
- Anti-Jo1 antibodies, which is associated with a more abrupt onset of fever, cracked hands, Raynaud's phenomenon, interstitial lung disease, arthritis, and a poor response to therapy. Anti-Jo1 antibodies are a type of anti-nuclear antibody. It has histidine-tRNA ligase as a target.
- Anti-signal recognition particle antibodies (anti-SRP), which are targeting signal recognition particle (SRP). Anti-SRP antibodies are mainly associated with, but are not very specific for, polymyositis. For individuals with polymyositis, the presence of anti-SRP antibodies are associated with more prominent muscle weakness and atrophy, and more cardiac manifestations.
- Anti-Mi-2 antibodies, which are associated with a better prognosis.
- ICD-10 > M33: Dermatopolymyositis
- Phillip R. J. Barnes; David Hilton-Jones (2003). Myopathies in Clinical Practice. Informa Health Care. pp. 85–. ISBN 978-1-899066-71-1. Retrieved 26 June 2010.
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- Kao, A. H.; Lacomis, D.; Lucas, M.; Fertig, N.; Oddis, C. V. (2004). "Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy". Arthritis & Rheumatism 50 (1): 209–215. doi:10.1002/art.11484. PMID 14730618.
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