Henrik Nicolai Clausen was born in the island of Lolland. From 1820 held a professorial chair in Theology at the University of Copenhagen where his theological rationalism influenced Magnús Eiríksson.
He wrote, besides other works, Romanism and Protestantism (1825); Popular Discourses on the Reformation (1836); a commentary on the synoptical Gospels, and Christian Dogmatics (1867).
In 1840 he was chosen a deputy to the States, and near the end of 1848 was appointed a member of the Cabinet of Moltke II. Died 28 March 1877. He was a member of the National Constitutional Assembly from 1848 to 1849, of the Folketing from 1849 to 1853 and of the Landsting from 1853 to 1863.