Henri Legrand du Saulle (16 April 1830 – 6 May 1886) was a French psychiatrist who was a native of Dijon.
As a young man he was an assistant to Bénédict Morel (1809-1873) at Saint-Yon, and also served under Louis-Florentin Calmeil (1798-1895) at the Charenton Asylum. In 1856 became a doctor to the medical faculty in Paris. Later he was appointed physician to the Bicêtre Hospital (replacing Prosper Lucas 1805-1885), and in 1879 succeeded Louis Delasiauve (1804-1893) as chief physician in the department for epileptics at Salpêtrière Hospital. During his career he also worked at the Dépôt de la Préfecture de police, from 1863 serving as médecin-adjoint to Charles Lasègue (1816-1883).
He is known for his studies on personality disorders, particularly pioneer work involving phobias and obsessive-compulsive disorders. He also performed extensive work in forensic psychiatry, being interested with the medical-judicial aspects of psychopathology.