HLA-DQ3

      		 This article provides insufficient context for those unfamiliar with the subject. Please help improve the article with a good introductory style. (October 2009)
      Illustration of HLA-DQ with peptide in the binding pocket
      major histocompatibility complex, class II, DQ3
      Haplotypes DQA1*0303:DQB1*0301 DQA1*0401:DQB1*0301 DQA1*0505:DQB1*0301 DQA1*0601:DQB1*0301 DQA1*03:DQB1*0302 DQA1*0301:DQB1*0303
      Structure (See HLA-DQ)
      Identifiers
      alpha 1 *0301 *0302 *0303 *0401 *0505 *0601
      Symbol(s) HLA-DQA1
      EBI-HLA DQA1*0301
      EBI-HLA DQA1*0302
      EBI-HLA DQA1*0303
      EBI-HLA DQA1*0401
      EBI-HLA DQA1*0505
      Identifiers
      beta 1 *0301 *0302 *0303
      Symbol(s) HLA-DQB1
      EBI-HLA DQB1*0301
      EBI-HLA DQB1*0302
      EBI-HLA DQB1*0303
      Shared data
      Locus chr.6 6p21.31

      HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3[1] a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2.[2] While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. For this reason they are best treated independently.

      Serology

      DQ3, DQ7, DQ8, and DQ9 recognition of Some DRB1*and [3]
      DQB1* DQ7 DQ3 DQ8 Sample
      allele  %  %  % size (N)
      0301 85 40 1 12220
      0304 40 35 8 111
      .
      DQ8 DQ3 DQ7 N
      0302 66 25 1 6657
      0305 34 30 70
      DQ9 DQ3 DQ2 N
      0303 67 12 11
      DQ7 DQ8 N
      0303 1 1 2563

      The serotyping efficiency of DQ3 recognition relative to DQ2, DQ7, DQ8, and DQ9 is shown to the left. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ3 recognition is relatively low and error prone. This compares to genotyping efficiency of 100%. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DBB1*group recognizes DQB1*0303 as efficiently as DQ3.

      For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study. Nonetheless, it is still widely used and association purported in the literature.

      ↑Jump back a section

      Alleles

      DQB1*0301

      DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7

      DQB1*0302

      DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8

      DQB1*0303

      DQB1*0303 the DQ9 gene, is detailed on HLA-DQ9

      DQB1*0304

      DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7

      DQB1*0305

      DQB1*0305 is similar in structure and function to DQB1*0302 generally considered to be HLA-DQ8

      ↑Jump back a section

      References

      1. ^ Goyert SM, Silver J (1983). "Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 80 (18): 5719–23. doi:10.1073/pnas.80.18.5719. PMC 384330. PMID 6193521. 
      2. ^ Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. 
      3. ^ derived from IMGT/HLA
      Genetic loci
      Serotypes
      ↑Jump back a section
      Last modified on 3 January 2013, at 01:43