HIST1H1B

Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene.

H1-5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2RHI
Identifiers
Aliases	H1-5, H1, H1.5, H1B, H1F5, H1s-3, histone cluster 1, H1b, histone cluster 1 H1 family member b, HIST1H1B, H1.5 linker histone, cluster member
External IDs	OMIM: 142711 HomoloGene: 136789 GeneCards: H1-5
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 27,866,792 bp End 27,867,588 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells tendon Achilles tendon ganglionic eminence thymus monocyte blood corpus callosum skeletal muscle tissue face n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone deacetylase binding chromatin DNA binding RNA binding protein binding double-stranded DNA binding nucleosomal DNA binding Cellular component nucleosome extracellular exosome chromosome nucleus Biological process establishment of protein localization to chromatin nucleosome assembly protein stabilization positive regulation of cell growth negative regulation of transcription by RNA polymerase II chromatin organization positive regulation of histone H3-K9 methylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination muscle organ development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3009 n/a Ensembl ENSG00000184357 n/a UniProt P16401 n/a RefSeq (mRNA) NM_005322 n/a RefSeq (protein) NP_005313 n/a Location (UCSC) Chr 6: 27.87 – 27.87 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Further reading

• Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d". J. Biochem. 106 (5): 844–57. doi:10.1093/oxfordjournals.jbchem.a122941. PMID 2613692.
• van Wijnen AJ, Wright KL, Massung RF, et al. (1988). "Two target sites for protein binding in the promoter region of a cell cycle regulated human H1 histone gene". Nucleic Acids Res. 16 (2): 571–92. doi:10.1093/nar/16.2.571. PMC 334679. PMID 2829131.
• Collar DG, Wright KL, van Wijnen AJ, et al. (1988). "The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells". J. Biol. Chem. 263 (31): 15860–3. doi:10.1016/S0021-9258(18)37527-6. PMID 3182772.
• Ohe Y, Hayashi H, Iwai K (1986). "Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b". J. Biochem. 100 (2): 359–68. doi:10.1093/oxfordjournals.jbchem.a121722. PMID 3782055.
• Carozzi N, Marashi F, Plumb M, et al. (1984). "Clustering of human H1 and core histone genes". Science. 224 (4653): 1115–7. Bibcode:1984Sci...224.1115C. doi:10.1126/science.6719136. PMID 6719136.
• Aprelikova O, Xiong Y, Liu ET (1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". J. Biol. Chem. 270 (31): 18195–7. doi:10.1074/jbc.270.31.18195. PMID 7629134.
• Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
• New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". J. Biol. Chem. 274 (2): 1026–32. doi:10.1074/jbc.274.2.1026. PMID 9873047.
• Chadwick BP, Willard HF (2001). "A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome". J. Cell Biol. 152 (2): 375–84. doi:10.1083/jcb.152.2.375. PMC 2199617. PMID 11266453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Giampuzzi M, Oleggini R, Di Donato A (2003). "Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved". Biochim. Biophys. Acta. 1647 (1–2): 245–51. doi:10.1016/s1570-9639(03)00059-1. PMID 12686141.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Vaquero A, Scher M, Lee D, et al. (2004). "Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin". Mol. Cell. 16 (1): 93–105. doi:10.1016/j.molcel.2004.08.031. PMID 15469825.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.