HFSS or HfSS may refer to:
- high-frequency structure simulator, a high frequency electromagnetic simulation software, see Ansys HFSS
- high in fat, sugar and salt, food products that are high in fat, sugar or salt, see junk food
- Hochschule für Sozialpädagogik und Sozialökonomie, a predecessor of the City University of Applied Sciences in Bremen, Germany
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