Guillermo Rodríguez may refer to:
- Guillermo Rodríguez (baseball), Venezuelan baseball catcher
- Guillermo Rodríguez (footballer), Uruguayan footballer
- Guillermo Rodríguez (athlete), Mexican Olympic sprinter
- Guillermo Rodríguez (politician), also known as Guillermo Rodríguez Lara, Ecuadorian politician
- Guillermo Rodríguez González, Spanish archer
- Guillermo Rodriguez (comedian), Recurring cast member of Jimmy Kimmel Live!
This disambiguation page lists articles about people with the same name.
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