In enzymology, a glucuronate-2-sulfatase (EC 3.1.6.18) is an enzyme that catalyzes the chemical reaction of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.
| glucuronate-2-sulfatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.6.18 | ||||||||
| CAS no. | 98597-45-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase. This enzyme is also called glucurono-2-sulfatase. This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.
References edit
- Shaklee PN, Glaser JH, Conrad HE (1985). "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans". J. Biol. Chem. 260 (16): 9146–9. PMID 4019466.
