GUCY1B3
Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[1][2]
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).[supplied by OMIM][2]
Interactions
GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[3] and Endothelial NOS.[3]
References
- ^ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
- ^ a b "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
- ^ a b Venema, Richard C; Venema Virginia J, Ju Hong, Harris M Brennan, Snead Connie, Jilling Tamas, Dimitropoulou Christiana, Maragoudakis Michael E, Catravas John D (Aug. 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. (United States) 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. ISSN 0363-6135. PMID 12676772.
Further reading
- Lucas KA, Pitari GM, Kazerounian S, et al. (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. PMID 10977868.
- Chhajlani V, Frändberg PA, Ahlner J, et al. (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. doi:10.1016/0014-5793(91)81248-7. PMID 1680753.
- Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
- Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
- Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
- Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Venema RC, Venema VJ, Ju H, et al. (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
- Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, et al. (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi:10.1038/sj.ijir.3901461. PMID 16528291.
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