GNAI1

GNAI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Identifiers
Aliases	GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB
External IDs	OMIM: 139310 MGI: 95771 HomoloGene: 74417 GeneCards: GNAI1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	80,226,181 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	18,565,353 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; germinal epithelium; ; pons; ; oocyte; ; secondary oocyte; ; superior vestibular nucleus; ; external globus pallidus; ; ganglionic eminence;
	Top expressed in
	substantia nigra; ; subiculum; ; barrel cortex; ; sciatic nerve; ; nucleus accumbens; ; white adipose tissue; ; Region I of hippocampus proper; ; cerebellar vermis; ; prefrontal cortex; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activating protein binding; nucleotide binding; G-protein beta/gamma-subunit complex binding; GDP binding; G protein-coupled serotonin receptor binding; signal transducer activity; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; GTP binding; magnesium ion binding; GTPase activity;
Cellular component	cytoplasm; centrosome; membrane; plasma membrane; intracellular anatomical structure; microtubule organizing center; lysosomal membrane; midbody; heterotrimeric G-protein complex; membrane raft; extracellular exosome; cytoskeleton; nucleus; nucleolus; cell cortex region; cell cortex; protein-containing complex;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; response to peptide hormone; negative regulation of synaptic transmission; cell division; cell cycle; signal transduction; regulation of cAMP-mediated signaling; cellular response to forskolin; protein folding; regulation of mitotic spindle organization; positive regulation of protein localization to cell cortex; transport; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2770
	14677
	ENSG00000127955
	ENSMUSG00000057614
	P63096
	B2RSH2
	NM_002069; NM_001256414
	NM_010305
	NP_001243343; NP_002060
	NP_034435
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.^[5]^[6]

Interactive pathway map edit

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions edit

GNAI1 has been shown to interact with:

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057614 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. Bibcode:1987PNAS...84.5115B. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
^ Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. S2CID 6604295.
^ ^a ^b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
^ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. Bibcode:2002Natur.416..878K. doi:10.1038/416878a. PMID 11976690. S2CID 4406208.
^ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
^ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Further reading edit

Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International Journal of Developmental Neuroscience. 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID 10978845. S2CID 21002590.
Brown EJ, Frazier WA (Mar 2001). "Integrin-associated protein (CD47) and its ligands". Trends in Cell Biology. 11 (3): 130–5. doi:10.1016/S0962-8924(00)01906-1. PMID 11306274.
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Jiang M, Pandey S, Tran VT, Fong HK (May 1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575.
Gennity JM, Siess W (Nov 1991). "Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets". The Biochemical Journal. 279 (Pt 3): 643–50. doi:10.1042/bj2790643. PMC 1151493. PMID 1953657.
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (May 1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs". The Journal of Biological Chemistry. 263 (14): 6656–64. doi:10.1016/S0021-9258(18)68692-2. PMID 2834384.
Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC (Jun 1988). "The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus". American Journal of Human Genetics. 42 (6): 884–8. PMC 1715192. PMID 3130752.
Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M, Nozawa Y (Sep 1988). "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin". FEBS Letters. 237 (1–2): 113–7. doi:10.1016/0014-5793(88)80182-0. PMID 3139448. S2CID 27091750.
Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y (Jul 1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein". Biochemical and Biophysical Research Communications. 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078.
Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T, Yumura W, Nihei H (Jan 1994). "Identification of GTP-binding proteins in human glomeruli". Nihon Jinzo Gakkai Shi. 36 (1): 9–12. PMID 8107314.
Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, Reisine T (Apr 1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology. 45 (4): 587–90. PMID 8183236.
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (Jun 1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology. 132 (6): 2484–90. doi:10.1210/endo.132.6.8504751. PMID 8504751.
Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.
De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (May 1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". Journal of Neurochemistry. 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280. S2CID 31928913.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127955 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057614 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3110783-5] Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. Bibcode:1987PNAS...84.5115B. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.

[6] "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".

[pmid10471510-8] Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics. 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. S2CID 6604295.

[pmid11387333-9] Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.

[pmid11976690-10] Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. Bibcode:2002Natur.416..878K. doi:10.1038/416878a. PMID 11976690. S2CID 4406208.

[pmid10364213-11] Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.

[pmid8986788-12] De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.

[pmid12509430-13] Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.

[pmid8626678-14] Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

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