GMEB1

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.

GMEB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OQJ
Identifiers
Aliases	GMEB1, P96PIF, PIF96, glucocorticoid modulatory element binding protein 1
External IDs	OMIM: 604409 MGI: 2135604 HomoloGene: 10647 GeneCards: GMEB1
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.3 Start 28,668,778 bp End 28,719,353 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.3 Start 132,221,025 bp End 132,261,602 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte tibia visceral pleura ganglionic eminence monocyte parietal pleura amniotic fluid germinal epithelium blood Top expressed in secondary oocyte fossa ureter primitive streak ganglionic eminence thymus trigeminal ganglion female urethra internal carotid artery condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA binding transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10691 56809 Ensembl ENSG00000162419 ENSMUSG00000028901 UniProt Q9Y692 Q9JL60 RefSeq (mRNA) NM_006582 NM_024482 NM_001319674 NM_001122992 NM_020273 RefSeq (protein) NP_001306603 NP_006573 NP_077808 NP_001116464 NP_064669 Location (UCSC) Chr 1: 28.67 – 28.72 Mb Chr 4: 132.22 – 132.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.

Interactions

GMEB1 has been shown to interact with TRIM63.

Further reading

• Jimenez-Lara AM, Heine MJ, Gronemeyer H (2000). "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family". FEBS Lett. 468 (2–3): 203–210. doi:10.1016/S0014-5793(00)01209-6. PMID 10692587.
• Zeng H, Kaul S, Simons SS (2000). "Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins". Nucleic Acids Res. 28 (8): 1819–1829. doi:10.1093/nar/28.8.1819. PMC 102812. PMID 10734202.
• Kaul S, Blackford JA, Chen J, Ogryzko VV, Simons SS (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–1027. doi:10.1210/mend.14.7.0494. PMID 10894151.
• Burnett E, Christensen J, Tattersall P (2002). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J. Mol. Biol. 314 (5): 1029–1039. doi:10.1006/jmbi.2000.5198. PMID 11743720.
• Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–12549. doi:10.1074/jbc.M112330200. PMID 11812797.
• Surdo PL, Bottomley MJ, Sattler M, Scheffzek K (2004). "Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions". Mol. Endocrinol. 17 (7): 1283–1295. doi:10.1210/me.2002-0409. PMID 12702733.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Tsuruma K, Nakagawa T, Shirakura H, Hayashi N, Uehara T, Nomura Y (2005). "Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain". Biochem. Biophys. Res. Commun. 325 (4): 1246–1251. doi:10.1016/j.bbrc.2004.10.145. PMID 15555560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y (2006). "Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury". J. Biol. Chem. 281 (16): 11397–11404. doi:10.1074/jbc.M510597200. hdl:2115/8511. PMID 16497673.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.