Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene .[5] [6]
Function
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Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus . Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm . Three transcript variants encoding the same protein have been found for this gene.[5]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000046647 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040621 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: gem (nuclear organelle) associated protein 8" .^ Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (March 2006). "Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly" . J. Biol. Chem . 281 (12): 8126–34. doi :10.1074/jbc.M512243200 PMID 16434402 .
Further reading
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Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex" . J. Biol. Chem . 281 (48): 37009–16. doi :10.1074/jbc.M607505200 PMID 17023415 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 .
