GAL3ST1

GAL3ST1
Identifiers
Aliases	GAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDs	OMIM: 602300 MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,574,665 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,949,326 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; putamen; ; duodenum; ; nucleus accumbens; ; amygdala; ; caudate nucleus; ; substantia nigra; ; sural nerve; ; jejunal mucosa; ; hippocampus proper;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; duodenum; ; anterior horn of spinal cord; ; sciatic nerve; ; optic nerve; ; proximal tubule; ; jejunum; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; galactosylceramide sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane;
Biological process	glycolipid biosynthetic process; myelination; galactosylceramide biosynthetic process; protein N-linked glycosylation; spermatogenesis; sphingolipid metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	9514
	53897
	ENSG00000128242
	ENSMUSG00000049721
	Q99999
	Q9JHE4
NM_004861; NM_001318103; NM_001318104; NM_001318105; NM_001318106;
	NM_001318107; NM_001318108; NM_001318109; NM_001318110; NM_001318111; NM_001318112; NM_001318113; NM_001318114; NM_001318115; NM_001318116
	NM_001177691; NM_001177703; NM_016922; NM_001382290; NM_001382291
NP_001305032; NP_001305033; NP_001305034; NP_001305035; NP_001305036;
	NP_001305037; NP_001305038; NP_001305039; NP_001305040; NP_001305041; NP_001305042; NP_001305043; NP_001305044; NP_001305045; NP_004852
	NP_001171162; NP_001171174; NP_058618; NP_001369219; NP_001369220
	Wikidata
View/Edit Human	View/Edit Mouse

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[5]^[6]^[7]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
^ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
^ ^a ^b "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading edit

Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta. 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955.
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. doi:10.1016/S0021-9258(18)61991-X. PMID 5562350.
Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086. S2CID 32069166.
Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451. S2CID 23693243.
Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9847074-5] Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

[pmid9030544-6] Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.

[entrez-7] "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

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