Frovatriptan, sold under the brand name Frova, is a triptan drug developed by Vernalis for the treatment of migraine headaches[1] and for short term prevention of menstrual migraine.[2] The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.[3]
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Trade names | Frova |
Other names | 6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide (6R)-6-methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604013 |
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Routes of administration | Oral |
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Pharmacokinetic data | |
Bioavailability | 20–30% |
Metabolism | Hepatic |
Elimination half-life | 26 hours |
Excretion | Renal |
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Chemical and physical data | |
Formula | C14H17N3O |
Molar mass | 243.310 g·mol−1 |
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Medical uses edit
Frovatriptan is used in the treatment of migraine.
Available forms edit
It is available as 2.5 mg tablets.
Contraindications edit
Frovatriptan should not be given to patients with:
- Ischemic heart disease
- Cerebrovascular syndrome
- Peripheral vascular disease
- Uncontrolled hypertension
- Hemiplegic or basilar migraine
Side effects edit
Rare, but serious cardiac events have been reported in patients with risk factors predictive of CAD. These include: coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation.
Pharmacology edit
Pharmacodynamics edit
Frovatriptan is a serotonin receptor agonist, with high affinity for the 5-HT1B/1D receptors. It has no significant effects on the GABAA mediated channel activity and benzodiazepine binding sites. Frovatriptan inhibits excessive dilation of arteries that supply blood to the head.
Pharmacokinetics edit
Frovatriptan has a terminal elimination half-life of approximately 26 hours, making it the longest within its class.[4]
Society and culture edit
US licensing edit
Frovatriptan is available only by prescription in the United States and Canada, where a secondary New Drug Approval (sNDA) was filed in July 2006.[5]
References edit
- ^ Allais G, Benedetto C (2016). "Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine". Drug Design, Development and Therapy. 10: 3225–3236. doi:10.2147/DDDT.S105932. PMC 5055118. PMID 27757013.
- ^ MacGregor EA (2014). "A review of frovatriptan for the treatment of menstrual migraine". International Journal of Women's Health. 6: 523–35. doi:10.2147/IJWH.S63444. PMC 4039425. PMID 24904224.
- ^ "Frova". Vernalis. Archived from the original on 2007-09-27. Retrieved 2007-11-28.
- ^ Balbisi, Ebrahim (September 2006). "Frovatriptan: A Review of Pharmacology, Pharmacokinetics and Clinical Potential in the Treatment of Menstrual Migraine". Therapeutics and Clinical Risk Management. 2 (3): 303–308. doi:10.2147/tcrm.2006.2.3.303. PMC 1936266. PMID 18360605.
- ^ "Patient Information Sheet -- Frovatriptan succinate (marketed as Frova)". Food and Drug Administration. July 2006. Archived from the original on 2007-09-29. Retrieved 2007-11-28.
External links edit
- Frova (manufacturer's website)
- Frovatriptan Succinate (patient information)
- FDA labeling