Frank O'Brien may refer to:
- Frank O'Brien (politician), Pennsylvania politician
- Frank O'Brien (footballer) (1900–1986), Australian rules footballer
- Frank O'Brien (rugby union) (1910–1984), Australian rugby union player
- Frank P. O'Brien, mayor of Birmingham, Alabama
- Dink O'Brien (Frank Aloysius O'Brien, 1894–1971), baseball player
See also
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This disambiguation page lists articles about people with the same name.
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