Fangchinoline

Fangchinoline
Names
	IUPAC name (1β)-6,6',12-trimethoxy-2,2'-dimethylberbaman-7-ol
Identifiers
CAS Number	436-77-1 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:132893;
ChemSpider	66173;
PubChem CID	73481;
UNII	953592C3ZB;
CompTox Dashboard (EPA)	DTXSID40893498 ;
	InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29-/m0/s1 Key: IIQSJHUEZBTSAT-VMPREFPWSA-N;
	SMILES C12=CC(=C3C=C1[C@@H](N(CC2)C)CC4=CC=C(C=C4)OC5=CC(C[C@]6(C=7C(=C(C(=CC7CCN6C)OC)O)O3)[H])=CC=C5OC)OC;
Properties
Chemical formula	C37H40N2O6
Molar mass	608.735 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Fangchinoline is a chemical compound isolated from Stephania tetrandra.^[1] It has in vitro antiproliferative activity against a breast cancer cell line.^[2]

References edit

^ Xie, Zhisheng; Xu, Xinjun; Xie, Chunyan; Liang, Zhikun; Yang, Mei; Huang, Jieyun; Yang, Depo (2014). "Preparative Isolation of Tetrandrine and Fangchinoline from Radix Stephania tetrandra Using Reversed-Phase Flash Chromatography". Journal of Liquid Chromatography & Related Technologies. 37 (3): 343–352. doi:10.1080/10826076.2012.745139. S2CID 97548321.
^ Xing, Z.; Zhang, Y.; Zhang, X.; Yang, Y.; Ma, Y.; Pang, D. (2013). "Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation". Phytotherapy Research. 27 (12): 1790–1794. doi:10.1002/ptr.4936. PMID 23401195. S2CID 32344652.

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